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KMID : 0616120170480010031
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 1 p.31 ~ p.37
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Effects of Allium hookeri Extracts on Glutamate-induced Neurotoxicity in HT22 Cells
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Kim Ji-Yun
Ko Won-Min
Kim Ae-Jung
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Abstract
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Glutamate-induced oxidative stress results in neuro-degenerative disorders in many central nervous system (CNS) such as Alzheimer`s disease, ischemia, Huntington`s disease, and Parkinson`s disease. Our study was performed to investigate neuroprotective effects of Allium hookeri extracts (leaf, root, and whole) on glutamate-induced HT22 cells. In this study, ethanol extract of A. hookeri showed the outstanding neuroprotective effect in HT22 cells. In addition, we found that ethanol extract of A. hookeri root increased heme oxygenase (HO)-1 in HT22 cells. Moreover, ethanol extract of A. hookeri root also upregulated nuclear accumulation of nuclear factor E2-related factor 2 (Nrf2) in HT22 cells. These results demonstrate that ethanol extract of A. hookeri root contributes neuroprotective effects against glutamate-induced oxidative stress in HT22 cells, via Nrf2- mediated HO-1 expression. Our study suggests that ethanol extract of A. hookeri root could be the potential agent for the treatment of many neuro-degenerative diseases.
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KEYWORD
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Allium hookeri, HT22 cells, Glutamate, Neuroprotective effect, Heme oxygenase-1, ROS
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